PAR-3 (1-6) amide (mouse) ( ——— )

产品货号. M41527 CAS No. 261521-21-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PAR-3 (1-6) amide (mouse)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SFNGGP-NH2 是一种有生物活性的肽。(PAR-3 是一种高亲和力凝血酶受体。 PAR-3 mRNA 在人类皮肤肥大细胞中表达。人们已经研究了蛋白酶激活受体 (PAR) 在瘙痒中的作用，并报道了它们通过组胺依赖性/独立途径产生的瘙痒相关反应。 PAR-3 已被证明不会单独引起瘙痒，但可能与 PAR-4 一起引起瘙痒。 PAR-3 和 PAR-4 的共表达增强了凝血酶作用，表明 PAR-3 单独不介导跨膜信号传导，而是作为激活 PAR-4 的辅助因子。)
产品描述

SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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